- Title
- Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole - results from the STARS II study
- Creator
- Veldhuyzen van Zanten, S.; Wahlqvist, P.; Talley, Nicholas J.; Halling, K.; Vakil, N.; Lauritsen, K.; Flook, N.; Persson, T.; Bolling-Sternevald, E.
- Relation
- Alimentary Pharmacology & Therapeutics Vol. 34, Issue 7, p. 714-723
- Publisher Link
- http://dx.doi.org/10.1111/j.1365-2036.2011.04789.x
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2011
- Description
- Background Patients with dyspepsia often experience troublesome symptoms. Aim: To assess the burden of uninvestigated dyspepsia (symptoms, health-related quality of life [HRQL] and work productivity) before and after 8 weeks’ esomeprazole treatment. Methods: Patients (n = 1250) with uninvestigated dyspepsia (no endoscopy within 6 months and ≤2 endoscopies within 10 years) underwent a 1-week esomeprazole acid-suppression test before randomisation to 7 weeks’ esomeprazole or placebo. The Reflux Disease Questionnaire (RDQ), Quality of Life in Reflux and Dyspepsia (QOLRAD) and Work Productivity and Activity Impairment (WPAI) questionnaires were completed at baseline (1-week off-treatment) and 8 weeks. WPAI results were further analysed among patients who responded to the acid-suppression test. Results: The highest baseline symptom score was for the RDQ dyspepsia domain, and the highest disease burden was for QOLRAD vitality and food/drink problems. After 8 weeks, significant improvements vs. placebo were observed for all RDQ and QOLRAD domains. The sub-population of acid-suppression test responders, but not the total WPAI population, had a significant work productivity improvement vs. placebo. Conclusions: Uninvestigated dyspepsia is associated with high symptom load and impacts on HRQL and work productivity. Esomeprazole improves HRQL among such patients, and improves work productivity among 1-week acid-suppression trial responders.
- Subject
- dyspepsia; esomeprazole; STARS II; health-related quality of life
- Identifier
- http://hdl.handle.net/1959.13/936693
- Identifier
- uon:12379
- Identifier
- ISSN:0269-2813
- Language
- eng
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